Center for Medical Research

Core Facility Mass Spectrometry

Mass spectrometry is a key technology in determining molecular compounds in cellular systems. The Core Facility Mass Spectrometry applies its technologies in the research fields of Lipidomics and Metabolomics, which encompass measurement of whole sets of lipids and metabolites. As of now, we are able to determine more than 10,000 individual lipids and metabolites with our technical settings, and we are constantly striving to increase this number. Our expertise has contributed to many projects that have arises from various research fields in recent years. Some exemplified core projects are highlighted below to exemplify ways to use our methods and expertise.

  • Determination of metabolic gluconeogenesis fluxes by 13C labelling experiments in lung tumors
    (collaboration with Katharina Leithner, Medizinische Universität Graz)
    Leithner et al., 2018 Proc Natl Acad Sci 24:6225-30
    Leithner et al., 2015 Oncogene 8:1044-50
  • Lipidomics of CNS and PNS contributes in uncovering new signaling pathways in neurobiology
    (collaboration with Ulrich Suter, ETH Zürich)
    Dimas et al., 2019 eLife, submitted
    Montani et al., 2018 J Cell Biol 217:1352-67
    Lebrun et al., 2014 J Neurosci 25:8432-48
    Norrmen et al., 2014 Cell Reports 9:646-660
  • Determination of the lipid composition of extracellular vesicles
    (collaboration with Soazig Le Lay, INSERM U1063 Angers)
    Durcin et al., 2018 J Extracell Ves 6:1305677
  • Identification of a novel therapeutic target for obesity by a non-targeted ligand search strategy
    (collaboration with Christian Wolfrum, ETH Zürich)
    Wolfrum et al., Nature Medicine, in revision
  • Lipidomics and Metabolomics as characterization tools for rare neuropediatric diseases
    (collaboration with Barbara Plecko-Startinig, Medizinische Universität Graz)
  • Clinical glucose tracer studies in diabetes research
    (collaboration with Werner Regittnig, Medizinische Universität Graz; external analytical laboratory for Covance Inc.)
    Trötzmüller et al., 2017 Anal Chem 89:12252-60
    Patent No: 17178182.6-1803 
  • Method development for quantitative determination of IGF and other growth hormones by mass spectrometry with the final goal to introduce these methods into modern laboratory medicine.
    (collaboration with Markus Herrmann, Medizinische Universität Graz)

 

 

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